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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Neurobiol Learn Mem. 2016 Oct 20;136:189–195. doi: 10.1016/j.nlm.2016.10.008

Figure 3.

Figure 3

Intra-BNST infusions of the 5-HT2C receptor antagonist RS-102221 reduce the enhancement of fear learning produced by systemic injections of the SSRI citalopram. A: Schematic of behavioral protocol. Animals received i.p. injections of either 0.9% saline or 10mg/kg citalopram 1 hr prior to fear conditioning and then intra-BNST infusions of vehicle or RS-102221 (1 µg/side) 15 min prior to fear conditioning. 24 hr later they were tested for long term memory (LTM). B: Mean ± SE percent freezing to the pre CS period (30 sec; PRE) and to the CS during fear conditioning. C: Mean ± SE percent freezing to the pre-CS and 10 CS tones 24 hr after training (left). Mean ± SE percent freezing of each group averaged across all 10 tones (right), *P<0.05.