Table 2.

Summary of experimental live RABV-based vaccines with potential to protect against lethal rabies.

Strain	Strategy	Target
HEP-Flury/SPBN	Deletion of the P gene	P
SAD	Insertion of an internal ribosome entry site to control P gene transcription	P
RC-HL/SPBN	Deletion of the M gene	M
SPBN	Mutation of the PPEY motif	M
SPBN/Flury-LEP/HEP-Flury	Overexpression of the G gene in the G and L gene interval	G
SPBN	Deletion of the cytoplasmic domain of G protein	G
ERA/SPBN/SAG	Point mutation of the G gene	G a
HEP-Flury	Insertion of an IFN-α gene in the G and L gene interval	IFN-α
SPBN	Insertion of an IFN-β gene in the G and L gene interval	IFN-β
SPBN	Insertion of an IFN-γ gene in the G and L gene interval	IFN-γ
SPBN	Insertion of a TNF-α gene in the G and L gene interval	TNF-α
SPBN	Insertion of a cytochrome c gene in the G and L gene interval	cytochrome c
HEP-Flury	Insertion of a MIP-1α gene in the G and L gene interval	MIP-1α
LBNSE	Insertion of a GM-CSF gene in the G and L gene interval	GM-CSF
LBNSE	Insertion of a Flagellin gene in the G and L gene interval	Flagellin
ERA	Insertion of a GnRH gene in the G and L gene interval	GnRH

TNF-α, tumor necrosis factor α; MIP-1α, macrophage inflammatory protein 1α; GnRH, gonadotropin-releasing hormone; ^a The point mutation of G gene strategy is always used in the form of expressing multiple copies of the mutated G gene or coupled with gene rearrangement strategy.