Table 2.
Effect of 14 daily s.c. doses of 10 mg/kg GRFT on a mouse hematological profile.
| Cell Type | Parameter | Unit | Day 14 | Day 21 | ||
|---|---|---|---|---|---|---|
| PBS | GRFT | PBS | GRFT | |||
| Leucocytes | WBC | k/μL | 7.9 ± 1.5 | 7.2 ± 0.5 | 8.3 ± 2.4 | 8.5 ± 1.6 |
| NE | k/μL | 1.7 ± 0.6 | 2.7 ± 0.2 | 2.1 ± 1.3 | 2.9 ± 1.0 | |
| LY | k/μL | 5.4 ± 0.7 | 3.6 ± 0.4 1 | 5.0 ± 0.6 | 4.3 ± 0.4 | |
| MO | k/μL | 0.6 ± 0.1 | 0.6 ± 0.1 | 0.9 ± 0.2 | 1.0 ± 0.5 | |
| EO | k/μL | 0.2 ± 0.1 | 0.3 ± 0.1 | 0.2 ± 0.3 | 0.3 ± 0.1 | |
| BA | k/μL | 0.1 ± 0.0 | 0.1 ± 0.0 | 0.1 ± 0.1 | 0.1 ± 0.0 | |
| Erythrocytes | RBC | M/µL | 9.4 ± 0.5 | 9.1 ± 0.7 | 9.8 ± 1.1 | 10.1 ± 2.3 |
| Hb | g/dL | 14.2 ± 1.0 | 13.2 ± 1.1 | 15.0 ± 0.8 | 15.1 ± 4.0 | |
| HCT | % | 57.9 ± 5.3 | 56.2 ± 5.5 | 59.4 ± 6.2 | 60.1 ± 14.9 | |
| MCV | fL | 61.4 ± 2.6 | 61.7 ± 1.2 | 60.6 ± 3.4 | 59.3 ± 1.5 | |
| MCH | pg | 15.1 ± 0.4 | 14.5 ± 0.6 | 15.3 ± 0.9 | 14.8 ± 0.7 | |
| MCHC | g/dL | 24.5 ± 0.6 | 23.5 ± 1.0 | 25.3 ± 1.7 | 25.0 ± 0.6 | |
| RDW | % | 17.3 ± 0.9 | 18.2 ± 0.5 | 18.0 ± 0.4 | 18.5 ± 0.4 | |
| Thrombocytes | PLT | k/μL | 1571.3 ± 100.8 | 1397.0 ± 302.5 | 850.0 ± 43.5 | 949.0 ± 211.5 |
| MPV | fL | 3.6 ± 0.1 | 3.7 ± 0.3 | 3.6 ± 0.2 | 3.8 ± 0.2 | |
Mice were treated with GRFT at 10 mg/kg for 14 days and samples were analyzed at the end of treatment, as well as seven days post-treatment. WBC, white blood cell; NE, neutrophil; LY, lymphocyte; MO, monocyte; EO, eosinophil; BA, basophil; RBC, red blood cell; Hb, hemoglobin; HCT, hematocrit; MCV, mean corpuscular volume; MCH, mean cell hemoglobin; MCHC, mean cell hemoglobin concentration; RDW, red cell distribution width; PLT, platelet; MPV, mean platelet volume. 1 Statistical significance at p < 0.05.