Table 3.

ART in HIV-infected patients with cryptococcosis

Time to start ART

Deferred until 5 weeks after the start of antifungal therapy

ART regimen

Consider drug–drug interactions between fluconazole and antiretroviral agents

Fluconazole may potentially increase PI concentrations, but no clinical significance

Fluconazole has the potential to increase NNRTI concentration

No significant interactions with efavirenz

Nevirapine has the most potential clinical relevancea

No significant interactions with rilpivirine

Monitor closely for nevirapine-associated adverse events, including hepatotoxicity

^aHIV-infected patients who received nevirapine, those also taking fluconazole 200 or 400 mg/day had nevirapine Cmin 76% higher, compared to those not taking fluconazole