TABLE 3.

Predictors to Continued Use of Medications for Infants Started Before 6 Months of Age (n = 743)

	Continue Use at 6 Months		Continued Use at 1 Year		Time to Discontinue GER Medicationsa
	(n = 607)		(n = 322)		(n = 812)
	aOR (95% CI)	P	aOR (95% CI)	P	HR (95% CI)	P
Gestational age category (wk)
<28	6.91 (2.18–21.86)	.001	3.11 (1.65–5.85)	.000	0.50 (0.38–0.66)	.000
28–<32	2.16 (1.26–3.71)	.005	1.76 (1.16–2.67)	.008	0.69 (0.57–0.84)	.000
32–<34	1.23 (0.75–2.02)	.42	1.07 (0.67–1.71)	.77	0.84 (0.69–1.03)	.09
34–35	Reference		Reference		Reference
Race/ethnicity
White	Reference		Reference		Reference
Black	0.59 (0.34–1.03)	.06	0.7 (0.43–1.13)	.14	1.17 (0.94–1.45)	.16
Asian	0.36 (0.09–1.36)	.13	0.72 (0.19–2.68)	.62	1.88 (1.04–3.43)	.04
Other/ Unknown	0.92 (0.47–1.79)	.81	0.57 (0.33–1.00)	.05	1.39 (1.09–1.77)	.007
Hispanic	1.15 (0.36–3.62)	.82	1.56 (0.66–3.69)	.31	092 (0.62–1.36)	.67
Male	1.19 (0.8–1.76)	.39	0.86 (0.63–1.19)	.38	0.93 (0.81–1.08)	.35
Multiple gestation	1.30 (0.86–1.97)	.22	0.73 (0.52–1.02)	.07	1.1 (0.94–1.27)	.23
Insurance group
Private	Reference		Reference		Reference
Any Medicaid	1.08 (0.62–1.87)	.79	0.62 (0.39–0.97)	.04	1.19 (0.96–1.46)	.11
Any self-pay	0.89 (0.51–1.54)	.67	1.01 (0.64–1.6)	.97	0.96 (0.78–1.17)	.67
Medical factors
Chronic lung disease	1.70 (0.52–5.55)	.38	2.59 (1.29–5.22)	.008	0.83 (0.62–1.12)	.22
Failure to thrive	1.77 (0.65–4.83)	.26	1.87 (0.97–3.62)	.06	0.62 (0.47–0.82)	.001
Airway malacia	2.07 (0.58–7.41)	.26	2.79 (1.24–6.3)	.01	0.75 (0.53–1.05)	.09
Feeding difficulties	1.03 (0.66–1.61)	.89	1.3 (0.9–1.88)	.16	0.87 (0.74–1.03)	.10
Dysphagia	0.57 (0.05–6.55)	.65	0.62 (0.09–4.08)	.62	1.06 (0.53–2.1)	.87
ALTE/apnea	0.77 (0.47–1.25)	.29	0.95 (0.64–1.4)	.80	1.03 (0.86–1.22)	.78
Tube feeding	1.67 (0.17–16.26)	.66	2.44 (0.55–10.8)	.24	0.55 (0.34–0.89)	.02
Supplemental oxygen	0.53 (0.15–1.86)	.32	1.58 (0.53–4.33)	.38	0.76 (0.52–1.11)	.16
Reactive airway disease	2.17 (1.09–4.3)	.03	1.67 (1.05–2.65)	.03	0.73 (0.6–0.89)	.002

HR, hazard ratio.

^aTime to discontinue all medications used a Cox proportional hazards model, where ratios <1 indicated longer use of medications, and ratios >1 indicated shorter use of medications compared with the reference category.