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. 2016 Nov 28;13:87. doi: 10.1186/s12986-016-0147-1

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Feeding regiment and experimental protocol. a Wild type (wt), Epac1^−/− and Epac2^−/− mice were divided into 6 groups exposed to either a normal chow diet (ND) or a high fat diet (HFD) for 33 ± 1 weeks. One intraperitoneal glucose tolerance test (ipGTT) was performed before start of the feeding experiment (baseline) and another 28 weeks into the feeding protocol. b At the end of the feeding experiment, the hearts were excised and mounted in a Langendorff perfusion system. Hearts were stabilized for 20min, before being subjected to 30min global ischemia (GI) and 60min of reperfusion (Rep)