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. 2016 Nov 28;13:87. doi: 10.1186/s12986-016-0147-1

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Myocardial tolerance to ischemia-reperfusion (I/R) injury after long-term feeding of an obesogenic high fat diet. Wild type (wt), Epac 1 (Epac1^−/−) and Epac 2 (Epac2^−/−) deficient mice were exposed to long-term feeding of either a normal chow diet (ND) or a high fat diet (HFD). At the end of the feeding protocol, the excised mice hearts were subjected to global ischemia (GI, 30min) and reperfusion (Rep, 60min) in a Langendorff perfusion model. Infarct size is expressed as percentage of the region at risk of infarction. Values are mean ± SEM and n ≥ 6. The numbers given in the figure indicate significance levels