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. 2016 Nov 28;35:184. doi: 10.1186/s13046-016-0463-3

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — GANT61 enhanced the DNA damage effect initiated by TMZ treatment. a Western blot analysis showed an obviously decreased expression of Gli1 and Gli2 in cells treated with a combination of GANT61 and TMZ, compared to TMZ-treated U251 and U87 glioma cells. Cells were continuously exposed to 5 μM GANT61 or 100 μM TMZ for up to 48 h. GAPDH was used as the loading control. b U87 and U251 cells were treated with 5 μM GANT61, 100 μM TMZ or a combination of the two treatments for 48 h. The γH2AX levels were measured by immunoblot assay. c Representative comet staining images in U87 and U251 cells after different treatments (5 μM GANT61, 100 μM TMZ or both). d Quantitative assessment of comet tail moment. **P < 0.01