Table 3.
Effects of dietary AFB1 and CM concentrations on the activities of chicken cytochrome P450 (CYP450) orthologs in the liver at week 2 1.
| Item | Control | AFB1 | CM | AFB1 + CM |
|---|---|---|---|---|
| CYP1A1, nmol/(mgprotein·min) | 0.34 ± 0.13 a | 1.26 ± 0.17 c | 0.83 ± 0.15 b | 0.79 ± 0.16 b |
| CYP1A2, nmol/(mgprotein·min) | 1.71 ± 0.45 a | 3.41 ± 0.49 b | 2.45 ± 0.63 a,b | 1.95 ± 0.55 a |
| CYP2A6, nmol/(mgprotein·min) | 2.07 ± 0.30 a | 5.89 ± 1.37 b | 3.00 ± 1.18 a | 3.08 ± 0.63 a |
| CYP3A4, nmol/(mgprotein·min) | 26.93 ± 2.22 a | 34.79 ± 3.06 b | 24.86 ± 1.51 a | 22.60 ± 2.26 a |
1 Values are expressed as means ± SD (n = 5), and means with different superscript letters differ (p < 0.05). AFB1, aflatoxin B1; CM, curcumin; CYP1A1, Cytochrome P450 1A1; CYP1A2, Cytochrome P450 1A2; CYP2A6, Cytochrome P450 2A6; CYP3A4, Cytochrome P450 3A4. Experimental details of Control and AFB1 groups are given in Sun et al. (2016) [12].