Table I.
Patient characteristics at first presentation to M. D. Anderson Cancer Center.
| Parameter | Number (n = 50) | Percentage | |
|---|---|---|---|
| Age (median, range) | 54 (29–78) | ||
| Sex | Male | 19 | 38 |
| Type of SM | ISM | 25 | 50 |
| ASM | 16 | 32 | |
| SM–AHNMD | 9 | 18 | |
| Hemoglobin (median, range) | 12.95 (9.2–15.6) | ||
| WBC (median, range) | 6.3 (2.3–49) | ||
| Platelets (median, range) | 246 (44–885) | ||
| Tryptase (median, range) | 55 (2–200) | ||
| Albumin (median, range) | 4.4 (2.4–5.2) | ||
| ALT (median, range) | 17.5 (11–82) | ||
| KITD816V mutation | Detected | 14 | 28 |
| Not detected | 14 | 28 | |
| ND | 22 | 44 | |
| B symptoms | Yes | 25 | 50 |
| No | 25 | 50 | |
| Cutaneous symptoms | Yes | 22 | 44 |
| No | 28 | 56 | |
| Splenomegaly | Yes | 5 | 10 |
| No | 44 | 88 | |
| Splenectomy | 1 | 2 | |
| Lymphadenopathy | 2 | 4 | |
| Cytogenetics | Diploid | 40 | 80 |
| Abnormal | 6 | 12 | |
| Insufficient metaphases | 4 | 8 | |
| Bone marrow cellularity | Hypocellular (< 30%) | 9 | 18 |
| Hypercellular (> 70%) | 10 | 20 | |
| Normocellular (30–70%) | 28 | 56 | |
| ND | 3 | 6 | |
| BM mast cell % | < 10 | 44 | 88 |
| 10–30 | 4 | 8 | |
| > 30 | 2 | 4 | |
| BM blast % | < 5 | 50 | 100 |
| 5–10 | 0 | 0 | |
| > 10 | 0 | 0 | |
| BM eosinophil % (median, range) | 3 (0–22) |
SM, systemic mastocytosis; ISM, indolent systemic mastocytosis; ASM, aggressive systemic mastocytosis; SM-AHNMD, SM associated with another clonal hematological non-mast cell lineage disease; WBC, white blood cells; ALT, alanine aminotransferase; ND, not done; BM, bone marrow.