Table 4.
Comparison of risk of renal outcomes of interest using SBP and DBP as linear predictors
| Model for SBP | HR (per 10 mmHg SBP increase) (95% CI) | P value | Model for DBP | HR (per 10 mmHg DBP increase) (95% CI) | P value |
|---|---|---|---|---|---|
| Macroalbuminuria | |||||
| Baseline SBP1 | 1.00 (0.86–1.17) | 0.98 | Baseline DBP1 | 1.04 (0.86–1.26) | 0.69 |
| Time-updated SBP | 1.44 (1.28–1.62) | <0.001 | Time-updated DBP | 1.32 (1.10–1.59) | 0.003 |
| Time-updated SBP and DBP in same model | 1.47 (1.28–1.69) | <0.001 | Time-updated SBP and DBP in same model | 0.95 (0.77–1.18) | 0.64 |
| Stage III CKD | |||||
| Baseline SBP1 | 0.96 (0.78–1.18) | 0.68 | Baseline DBP1 | 1.23 (0.94–1.61) | 0.13 |
| Time-updated SBP | 1.34 (1.16–1.54) | <0.001 | Time-updated DBP | 1.41 (1.09–1.82) | 0.009 |
| Time-updated SBP and DBP in same model | 1.32 (1.11–1.57) | 0.002 | Time-updated SBP and DBP in same model | 1.04 (0.76–1.43) | 0.78 |
All models were adjusted for age, race, sex, education, family history of hypertension, trial arm, and time-dependent covariates, including BMI, use of any antihypertensive medication, albuminuria, eGFR, smoking status, hemoglobin A1c, and use of ACE inhibitors or ARB (all with 1-year lag), unless otherwise specified. HR, hazard ratio.
1Models were adjusted for baseline age, sex, race, education level, family history of hypertension, smoking status, albuminuria, eGFR, trial arm, and BMI.