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. 2016 Sep 27;65(12):3598–3609. doi: 10.2337/db16-0649

Figure 2.

Figure 2

Hepatic-derived IGF-1 improves systemic glucose homeostasis in the Li-GHRKO mice. Blood glucose levels (A) and serum insulin levels (B) were determined in male mice at 16 weeks of age. Intraperitoneal glucose tolerance test (C) and intraperitoneal insulin tolerance test (D) performed in 16- to 20-week-old male mice in the fed state. E: Serum IGFBP-1 levels determined in male mice at 16–24 weeks of age. F: iPTT performed in 16- to 20-week-old male mice. Data presented as mean ± SEM. N indicates sample size. Significance accepted at P < 0.05: control vs. Li-GHRKO (a), control vs. Li-GHRKO-HIT (b), Li-GHRKO vs. Li-GHRKO-HIT (d), Li-GHRKO vs. HIT (e), and Li-GHRKO-HIT vs. HIT (f).