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. Author manuscript; available in PMC: 2017 Nov 14.
Published in final edited form as: Cancer Cell. 2016 Nov 3;30(5):750–763. doi: 10.1016/j.ccell.2016.10.005

Figure 8. SF3B1 mutation modulates Notch signaling through a splice variant of DVL2.

Figure 8

(A) Detection of DVL2 expression in OCI-Ly1 B cell lymphoma cells with stable expression of wild-type (WT), altered (ALT), or combined wild-type and altered forms (WT+ALT) of DVL2 by immunoblot.

(B) Activation of Notch1 in OCI-Ly1 cells expressing different DVL2 isoforms co-cultured with OP9 or OP9-DL1 cells for 48 hours assessed by immunoblot.

(C) Expression of the Notch target gene HES1 in OCI-Ly1 cells described in Figure 8A co-cultured with either OP9 or OP9-DL1 cells was measured by qRT-PCR. Red line indicates mean. See also Figure S7.