Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Nov 3;113(47):13408–13413. doi: 10.1073/pnas.1614970113

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Freely available online through the PNAS open access option.

PMC Copyright notice

Fig. 5. — Before initiation of angiogenesis in the pituitary gland, integrin β1-dependent transcriptome encodes ECM and associated factors critical for angiogenesis. (A) Midsagittal sections of e12.5 Itgb1^f/f and Itgb1^f/f; Pitx1-cre pituitaries immunostained with integrin β1 and CD31 1 d before initiation of angiogenesis. (Scale bar: 62.5 μm.) (B) RNA-seq analysis of pituitaries dissected from Itgb1^f/f and Itgb1^f/f; Pitx1-cre embryos at e12.5 identified 496 down-regulated and 642 up-regulated genes. Gene ontology analysis revealed significant changes in categories of genes encoding intrinsic and extrinsic factors. (C) Heat maps with identity of genes that encode ECM and related proteins. (D) Model for function of pituitary gland epithelial cell integrin β1 in developmental angiogenesis.