Table 2.

Results from Cox proportional hazard models predicting parental mortality risk from offspring education polygenic profile score

Parent	Cohort	n Offspring	n Parental deaths	HR (95% CI)	SE	P value
Mother	Generation Scotland	16,670	6,330	0.954 (0.907, 1.001)	0.024	0.056
	UK Biobank	115,323	69,990	0.976 (0.968, 0.984)	0.004	1.52 × 10−10
	Estonian Biobank	5,929	2,682	0.979 (0.940, 1.018)	0.020	0.280
	Meta-analysis	137,922	79,702	0.976 (0.968, 0.983)	0.004	8.21 × 10−10
Father	Generation Scotland	16,390	8,467	0.932 (0.891, 0.973)	0.021	0.0007
	UK Biobank	111,334	85,419	0.975 (0.969, 0.981)	0.003	2.05 × 10−13
	Estonian Biobank	6,097	3,744	0.942 (0.909, 0.975)	0.017	0.0003
	Meta-analysis	133,821	97,630	0.973 (0.967, 0.979)	0.004	1.73 × 10−18

Hazard ratios are expressed per SD of polygenic profile score. Meta-analytic rows are in bold. All models adjusted for offspring sex, genotyping array, and SNP principal components as described in Materials and Methods.