Fig. S3.

Mathematical simulations of Per2 and p53 distribution in total extracts. Simulated total levels of Per2 (dashed black line), p53 (solid purple line), monoubiquitinated p53 (solid green line), polyubiquitinated p53 (solid blue line), and nonubiquitinated p53 associated to Per2 (solid red line) in total extracts. As shown, the rhythms of p53 and Per2 show the same phase relationship as the experimental data in Fig. 1A.