Fig. 6.

Effect of Calindol on pre-contracted arteries and VGCC activity. (A) and (B) Mean data showing that Calindol induced vasorelaxations of methoxamine-induced pre-contracted endothelium-intact and endothelium-removed vessels. Note that Calindol-induced vasorelaxations are slightly attenuated when vessels are pre-contracted with 60 mM KCl. (C) Mean data showing that the presence of 3 µm Calhex has no effect on Calindol-induced relaxations of methoxamine-evoked arteries. **P<0.01, ***P<0.001, ***P<0.001, 2-way ANOVA followed by Bonferroni post hoc test. (D) Mean data showing that increasing concentrations of Calindol inhibited whole-cell VGCC currents. n=7 patches from n=3–4 animals. ****P<0.0001.