Table 1.

The effect of the various modulators tested on pre-contracted rabbit mesenteric arteries. Data are presented as mean values±SEM. IC₅₀ and E_max values were compared with using Student's t-test. n=4 animals used for each experiment, with at least 3 vessel segments per animal.

Calhex-231 on 10 µM Methoxamine pre-contracted tone

	IC50(µM)	Emax(%)
+Endothelium	2.01±0.61	96.2±2.3
−Endothelium	2.00±0.27	94.4±3.1
+1 µM Calindol	2.08±0.19	92±5.4
Calhex−231 on 60 mM KCl pre-contracted tone
+Endothelium	1.93±0.40	98±1.5
−Endothelium	2.02±0.23	97.1±2.2
NPS 2143 on - Endothelium pre-contracted vessels
Methoxamine	2.97±0.34		99.1±3.2
KCl	12.5±0.73a		78.4±3.4a
Calindol on 10 µM Methoxamine pre-contracted tone
+Endothelium	2.06±0.24			96.48±1.4
−Endothelium	2.66±0.30			94.4±2.8
+3 µM Calhex−231	2.58±0.35			97.2±1.1
Calindol on 60 mM KCl pre-contracted tone
+Endothelium	3.26±0.24b			82.2±2.3b
−Endothelium	3.41±0.32c			83.4±1.6c

^aP<0.05 vs. the effect of NPS 2143 on 10 µm Methoxamine pre-contracted tone.

^bP<0.05 vs. the effect of calindol on 10 µm Methoxamine precontracted tone in vessels with a functional endothelium (+endothelium).

^cP<0.01 vs. the effect of calindol on 10 µm Methoxamine precontracted tone in vessels lacking a functional endothelium (−endothelium).