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. 2016 Nov 29;11(11):e0167274. doi: 10.1371/journal.pone.0167274

Fig 2. MRI protocol for this study.

Fig 2

T1-weighted MPRAGE image (T1, left) in two different axial planes of a 17y-old typically developing subject indicating the measurement ROIs guided by the cortico-spinal tract fibre s outlined in red: frontal WM (in blue), cortico-spinal tract at the level of the centrum semiovale (in green) and at the level of the posterior limb of the internal capsule (in yellow). Other image parameters included in the protocol were T2-weighted axial TSE (T2), mean diffusivity (MD), fractional anisotropy (FA), intracellular volume fraction (ICVF), orientation dispersion (ODI), Magnetization Transfer Ratio (MTR), Myelin Water Fraction (MWF), Chemical Shift Imaging (CSI)–MR Spectroscopy, and quantitative susceptibility mapping (QSM, the white matter fibers have been highlighted by rendering diamagnetic effects bright, and paramagnetic dark).