Table 1. Measurement results in the three regions of interest: the frontal WM, the CST at the level of the centrum semiovale (CST-CS), and at the level of the posterior limb of the internal capsule (CST-PLIC).

Parameter	Frontal WM		CST–CS		CST–PLIC		T-score(paired t-test)
	mean	SD	mean	SD	mean	SD	frontal vs CST-CS	CST-CS vs PLIC
MD	0.810	0.032	0.740	0.028	0.752	0.025	10.3***	-1.81
FA	0.440	0.061	0.488	0.057	0.778	0.035	-3.03**	-19.2***
λ1	1.207	0.078	1.179	0.089	1.611	0.082	1.44	-17.4***
λ(2+3)*0.5	0.611	0.046	0.523	0.035	0.318	0.035	7.03***	17.8***
MK	0.972	0.074	1.144	0.075	1.392	0.132	-13.2***	-8.26***
RK	1.227	0.144	1.601	0.138	2.600	0.463	-12.0***	-9.36***
AK	0.732	0.063	0.814	0.091	0.604	0.056	-3.34**	7.33***
ICVF	0.551	0.038	0.656	0.038	0.745	0.067	-15.0***	-5.73***
ODI	0.230	0.036	0.215	0.027	0.104	0.019	1.53	15.4***
ISO	0.045	0.025	0.067	0.020	0.106	0.035	-4.38***	-4.94***
NAA/Cr (CSI)	2.422	0.188	2.828	0.270			-5.48***
Cho/Cr (CSI)	0.278	0.034	0.238	0.019			4.03**
NAA/Cr (SV)	2.266	0.365	2.556	0.420			-3.28*
Cho/Cr (SV)	0.295	0.019	0.250	0.020			7.34***
MWF	0.053	0.033	0.125	0.034			-12.0***
MTR	38.91	1.842	38.08	1.519	40.94	1.803	3.06**	-10.09***
QSM	0.0024	0.0079	0.0023	0.0093	-0.1238	0.0589	0.025	4.28***
R2*	17.97	1.380	18.54	0.680	18.17	2.917	-1.575	0.355

Units of diffusivities are given in μm²/ms. Statistically significant differences are highlighted in bold script (*p<0.05, **p<0.01, ***p<0.001).