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. Author manuscript; available in PMC: 2017 Jun 15.
Published in final edited form as: Brain Res. 2015 Dec 10;1641(Pt B):306–319. doi: 10.1016/j.brainres.2015.11.039

Figure 4.

Figure 4

The effect of various doses of MPH on performance in low and high performance groups. A range of MPH doses (2, 8, 16 mg/kg p.o.) were administered in each animal over multiple testing sessions. The low and high doses of did not affect performance in either group significantly. The moderate dose, which produces a clinically relevant blood plasma concentration comparable to that found in ADHD patients being treated with MPH, significantly improved performance in low baseline animals, but had no effect on high baseline animals [F(1,23)=9.190, p<0.01]. These results demonstrate a dose dependent and subject specific effect of MPH.