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Schematic diagram describing the synthesis of MC-containing PLGA scaffolds, and subsequent use for the repair of calvarial defects in mice. (Top) MC DNA is derived from a parent plasmid by removal of the bacterial cassette (BC). MC DNA is then fused with PLGA under supercritical CO2. (Bottom) Scaffold containing BMP-2 MC DNA is implanted into a mouse critical-size calvarial defect model for bone repair.
