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. 2016 Nov 14;126(12):4690–4701. doi: 10.1172/JCI88590

Figure 2. Spatial distribution of MAPs along source proteins.

Figure 2

(A) Distribution of overlap types for 3,682 pairs of overlapping MAPs formed by 5,046 individual peptides: pairs with any overlapping residues and no common ends; pairs with a common C terminus (C term); pairs with a common N terminus; and pairs with 1 peptide contained within the other. (B) Proportion of overlapping MAP pairs presented by the same allotype or different allotypes. For MAP pairs presented by different allotypes, whether the 2 allotypes belong to the same superfamily is indicated (34). (C) Distances between MAP start sites along proteins generating more than 1 MAP compared with a matched, random distribution. Distances are shown up to 30 residues. Distances are significantly shorter in the actual distribution (Wilcoxon rank sum test, P = 7 × 10-52). (D) Exome coverage by the immunopeptidome. A window of 50 or 25 amino acids (left and right panel, respectively) was moved residue by residue along proteins of the transcribed exome of B-LCLs. Histograms show the number of MAPs found in each window; the proportion of windows containing 0 versus at least 1 MAP is indicated.