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. Author manuscript; available in PMC: 2016 Nov 29.
Published in final edited form as: Annu Rev Pathol. 2013 Sep 16;9:219–238. doi: 10.1146/annurev-pathol-012513-104653

Figure 1.

Figure 1

Histopathology of Cryptococcus neoformans lung infection. Photomicrographs of lung tissue from Balb/c mice infected with C. neoformans (blue arrowheads), stained with hematoxylin and eosin. (a) Initial infection, showing diffuse pneumonitis and infiltration of immune cells and yeast into the alveolar space (200×). (b) Typical granuloma formation 5 days postinfection (200×). (c) Typical granuloma formation 15 days postinfection (100×). (d) Magnification of panel c, showing the presence of histiocytes (red arrowheads) (400×). (e) At later stages of infection, giant cells (yellow arrowhead) contain C. neoformans (400×). (f) C. neoformans replicating within the alveolar space, visualized by periodic acid–Schiff stain (400×).