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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Prog Lipid Res. 2016 Aug 12;64:69–84. doi: 10.1016/j.plipres.2016.08.003

Figure 4. MprF-mediated bacterial CAMP resistance.

Figure 4

MprF is a bifunctional protein. Its synthase domain (S) transfers lysine from lysyl-tRNA to phosphatidylglycerol (PG) to synthesize lysyl-PG, whereas its flippase domain (F) transfers lysyl-PG across the inner membrane to the exoplasmic/periplasmic side. Negatively charged PG attracts cationic anti-microbial peptides (CAMPs), whereas lysyl-PG being neutral does not.