Table 1.
HPV197 E6 associated cellular proteins previously identified in association with high-risk (HPV16, HPV18), low risk (HPV6, HPV11) and beta HPV (HPV5, HPV8) E6 proteins
| HPV5 NE61 |
HPV8 NE61 |
HPV6 NE61 |
HPV11 NE61 |
HPV16 NE61 |
HPV18 NE61 |
HPV197 CE6 Unique/Total/Coverage |
HPV197 NE6 Unique/Total/Coverage |
|---|---|---|---|---|---|---|---|
| ANKRD13A | ND | ND | |||||
| COL6A2 | ND | ND | |||||
| GALNT6 | ND | ND | |||||
| HERC2 | 8/9/3.10 % | 2/2/0.79 % | |||||
| KPNB1 | 18/20/26.48 % | 10/10/15.98 % | |||||
| MMP14 | ND | ND | |||||
| PDZRN3 | ND | ND | |||||
| PFKP | 23/26/32.40 % | 13/13/23.47 % | |||||
| PPP2R1A | 12/15/26.99 % | 9/11/17.83 % | |||||
| PPP2R2A | 10/13/31.54 % | 7/7/20.13 % | |||||
| PSMA1 | 4/4/14.83 % | ND | |||||
| PSMA4 | PSMA4 | 2/2/6.51 % | ND | ||||
| PSMA5 | ND | ND | |||||
| PSMA6 | PSMA6 | 3/3/15.45 % | ND | ||||
| PSMB1 | 1/1/8.30 % | 1/1/7.47 % | |||||
| PSMB2 | ND | ND | |||||
| PSMB4 | 5/6/29.17 % | 2/2/14.77 % | |||||
| PSMC1 | PSMC1 | 35/91/62.05 % | 28/57/64.55 % | ||||
| PSMC2 | PSMC2 | 32/69/55.66 % | 29/52/54.04 | ||||
| PSMC3 | PSMC3 | 39/90/65.15 % | 32/47/60.83 % | ||||
| PSMC4 | PSMC4 | 31/63/58.37 % | 25/41/61.24 % | ||||
| PSMC5 | PSMC5 | 34/82/54.68 % | 30/47/53.20 % | ||||
| PSMC6 | PSMC6 | 24/44/53.98 % | 22/32/53.73 % | ||||
| PSMD1 | PSMD1 | 52/106/54.35 % | 41/70/44.60 % | ||||
| PSMD3 | PSMD3 | 42/88/64.04 % | 38/68/59.93 % | ||||
| PSMD4 | PSMD4 | 11/19/28.38 % | 8/11/26.26 % | ||||
| PSMD6 | 31/55/66.84 % | 22/32/61.44 % | |||||
| PSMD7 | PSMD7 | 16/37/45.37 % | 12/24/42.28 % | ||||
| PSMD8 | PSMD8 | 13/25/37.43 % | 9/13/23.71 % | ||||
| PSMD11 | PSMD11 | 30/57/ 64.45 % | 26/46/57.35 % | ||||
| PSMD12 | PSMD12 | 30/51/48.03 % | 27/36/46.93 % | ||||
| PSMD13 | PSMD13 | PSMD13 | 23/36/53.46 % | 19/26/46.81 % | |||
| PSMD14 | PSMD14 | 19/34/57.42 % | 16/22/61.94 % | ||||
| RPL36AL | ND | ND | |||||
| RTCD1 | ND | ND | |||||
| SMU1 | ND | ND | |||||
| SNTB2 | 1/1/1.67 % | 1/1/1.67 % | |||||
| SNX27 | 1/1/2.59 % | ND | |||||
| SRBD1 | ND | ND | |||||
| SURF4 | SURF4 | ND | ND | ||||
| TOMM2 | ND | ND | |||||
| TP53 | 10/14/24.94 % | 6/6/16.03 % | |||||
| TRIM24 | ND | ND | |||||
| UBE3A | UBE3A | UBE3A | UBE3A | 31/32/39.66 % | 15/17/21.37 % | ||
| UTRN | 2/2/0.90 % | 2/2/1.05 % | |||||
| ZFR | ND | ND | |||||
| CCDC165 | ND | ND | |||||
| CD2BP2 | ND | ND | |||||
| CLUH | ND | ND | |||||
| COL6A1 | COL6A1 | 4/4/5.74 % | ND | ||||
| CREBBP | CREBBP | ND | ND | ||||
| CTTNBP2NL | ND | ND | |||||
| EP300 | EP300 | ND | ND | ||||
| FASN | 84/125/42.73 % | 66/83/35.96 % | |||||
| GFPT1 | 33/38/47.07 % | 22/23/35.19 % | |||||
| GJA1 | ND | ND | |||||
| HDGFRP2 | ND | ND | |||||
| INF2 | ND | ND | |||||
| IWS1 | ND | ND | |||||
| KANK2 | 7/7/10.34 % | 8/8/10.81 % | |||||
| LRPPRC | 7/8/7.68 % | 2/2/2.08 % | |||||
| MAML1 | 19/21/34.84 % | 6/7/14.27 % | |||||
| MAP3K11 | ND | ND | |||||
| MBOAT7 | MBOAT7 | ND | ND | ||||
| MCM3 | 30/34/54.70 % | 18/19/31.44 % | |||||
| MCM5 | 15/16/22.75 % | 9/9/16.76 | |||||
| MMS19 | 2/2/3.69 % | 3/3/5.15 % | |||||
| MTA2 | 2/2/3.69 % | 2/3/5.39 % | |||||
| NUP153 | 8/9/9.63 % | 1/1/0.75 % | |||||
| PDLIM7 | 1/1/2.41 % | 4/4/15.32 % | |||||
| PDZD11 | ND | ND | |||||
| PFKM | 31/53/40.13 % | 28/41/39.62 % | |||||
| PFN2 | 2/2/15.71 % | 1/1/4.26 % | |||||
| PPM1B | ND | ND | |||||
| PXN | 19/28/37.56 % | 14/18/35.87 % | |||||
| SHC1 | ND | ND | |||||
| SIK3 | 8/9/7.68 % | 6/6/6.41 % | |||||
| SMAD3 | ND | ND | |||||
| SOGA1 | ND | ND | |||||
| SQRDL | SQRDL | 6/6/16.67 % | 1/1/3.33 % | ||||
| SRPR | 2/2/4.39 % | ND | |||||
| SRPRB | SRPRB | 2/2/11.81 % | 2/4/11.81 % | ||||
| STARD13 | ND | ND | |||||
| TNC | ND | ND | |||||
| TNS3 | ND | ND | |||||
| TRAFD1 | 2/3/5.15 % | 1/1/2.06 % | |||||
| TRAM1 | ND | ND | |||||
| VKORC1 | VKORC1 | ND | ND | ||||
| VPS11 | ND | ND | |||||
| ZHX2 | ND | ND | |||||
| ATP2A2 | ATP2A2 | 8/8/21.98 % | 6/6/14.11 % | ||||
| CCT6A | CCT6A | 11/11/33.15 % | 8/8/26.74 % | ||||
| CNP | CNP | 7/9/14.96 % | ND | ||||
| JAK1 | JAK1 | ND | ND | ||||
| LOX | LOX | ND | ND | ||||
| PLEKHA5 | PLEKHA5 | ND | ND | ||||
| RNH1 | RNH1 | 6/7/14.53 % | 4/4/11.28 % | ||||
| RPL13A | RPL13A | 1/1/12.32 % | ND | ||||
| RPS27 | RPS27 | 1/1/28.57 % | 1/1/28.57 % | ||||
| SEPT9 | SEPT9 | 5/5/8.87 % | 1/1/2.56 % | ||||
| SRRM2 | SRRM2 | 7/7/3.74 % | 9/9/4.11 % | ||||
| UBR5 | UBR5 | 8/8/4.89 % | 1/1/0.43 % |
ND Not Detected
1
Data from (Rozenblatt-Rosen et al., 2012; White et al., 2012a). Data were only included if an interaction was detected in at least 2 independent experiments.