Skip to main content
. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Nat Neurosci. 2016 Sep 12;19(12):1583–1591. doi: 10.1038/nn.4388

Figure 7. SLAVs are composed of two classes of variants.

Figure 7

For somatic L1 insertions, a germline-inherited LINE-1 sequence is transcribed into RNA. The L1 endonuclease and reverse transcriptase protein nicks the genomic DNA and reverse transcribes the L1 RNA, resulting in the insertion of a new copy of Line-1 sequence. For retrotransposition-independent SLAVs, L1 endonuclease preferentially cuts a a germline-inherited LINE-1 sequence and recombination with a downstream A microsatellite results in a microhomology-mediated deletion. The A microsatellite regions may be nicked by the L1 endonuclease or a fragile site within the genome of neural progenitor cells.