Table 1.
Bioelectrical characteristics of NGC neurons that changed in Trends over P3-P6 of age. Results are presented as M±SEM (n) in this and other tables.
| P3 | P4 | P5 | P6 | Trenda | P3 vs P6b | ||
|---|---|---|---|---|---|---|---|
| Action potential |
Neurons with AP train (% ) |
17 (2/12) |
33 (6/18) |
38 (6/16) |
80 (12/15) |
p< 0.05 | p<0.01c |
| Amplitude (mV) |
47.7 ± 2.0 (8) |
49.0 ± 3.0 (6) |
52.0 ± 2.9 (8) |
56.0 ± 2.5 (14) |
p< 0.05 | p<0.05 | |
| Threshold (mV) |
−30.8 ± 1.8 (8) |
−34.2 ± 1.0 (6) |
−37.2 ± 2.1 (8) |
−38.2 ± 2.4 (13) |
p< 0.05 | p<0.01 | |
| Currents by single voltage step |
Inward (pA) |
−1366 ± 144 (12) |
−2099 ± 292 (18) |
−2207 ± 291 (16) |
−2689 ± 270 (15) |
p< 0.05 | p<0.001 |
| Outward (pA) |
1427 ± 353 (12) |
3220 ± 598 (18) |
4132 ± 730 (16) |
5312 ± 852 (15) |
p< 0.05 | p<0.001 | |
| Currents by multiple voltage steps |
Neg Pk (pA) Vh −70 mVe |
−1110 ± 243 (12) |
−2075 ± 27 (18) |
−2389 ± 351 (16) |
−3161 ± 443 (15) |
p< 0.05 | p<0.001 |
| Neg Pk (pA) Vh −40 mV |
−1273 ± 88 (12) |
−1667 ± 250 (18) |
−1790 ± 209 (16) |
−2461 ± 344 (15) |
p< 0.05 | p<0.01 | |
| Steady State Current (pA) |
3160 ± 299 (12) |
4447 ± 389 (18) |
4473 ± 515 (16) |
4829 ± 438 (15) |
p< 0.05 | p<0.01 | |
| EPSCs | Amplitude (pA) |
57.9 ± 11.1 (6) |
49.3 ± 3.1 (39) |
49.2 ± 4.3 (18) |
40.8 ± 1.8 (28) |
p<0.05 | p<0.01 |
| Area (arbitrary unit) |
97.6 ± 28.6 (6) |
91.4 ± 10.0 (39) |
67.7 ± 6.2 (18) |
55.6 ± 3.5 (28) |
p<0.05 | p<0.01 | |
a
Mann-Kendall test for Trend, one-tailed.
b
ANOVA, two-tailed.
c
χ2 test, 2-tailed.