Table 2.
Bioelectrical characteristics of NGC neurons that did not change in Trends over P3-P6 of age. Results are presented as M±SEM (n) in this and other tables.
| P3 | P4 | P5 | P6 | Trenda | P3 vs P6 | ||
|---|---|---|---|---|---|---|---|
| Action Potential |
Neurons with single AP (%) |
50 (6/12) |
0 (0/18) |
13 (2/15) | 14 (2/14) | ns | p<0.05c |
| Currents by multiple voltage steps |
Positive Peak (pA) |
3501 ± 245 (12) |
4653 ± 478 (18) |
4594 ± 577 (16) | 5327 ± 543 (15) | ns | p<0.01b |
| Rapid activating Current (pA) |
913 ± 126 (12) |
811 ±149 (17) |
684 ± 97 (14) | 940 ± 122 (15) | ns | nsb | |
| Fast activating Current (pA) |
341 ± 180 (12) |
206 ±167 (18) |
121 ± 219 (16) | 498 ± 161 (15) | ns | nsb | |
| Negative Peak Position (pA) |
−18.7 ± 2.9 (12) |
−29.2 ± 2.5 (18) |
−37.0 ± 2.0 (15) | −29.6 ± 4.0 (14) | ns | p<0.05b 1-tailed |
|
| EPSCs | Neurons with EPSCs, % (n/n) |
42% (5/12) |
39% (7/18) |
38% (6/16) |
43% (6/14) |
ns | nsc |
| EPSCs frequency (Hz) |
2.4 ± 0.4 (5) |
10.9 ± 4.7 (7) |
6.0 ± 2.0 (6) |
9.3 ± 3.4 (6) |
ns | nsb | |
| Neurons responded to: % (n/n) |
HA | 100% (7/7) |
89% (8/9) |
83% (5/6) |
86% (6/7) |
ns | nsc |
| Glut | 67% (4/6) |
71% (5/7) |
67% (4/6) |
67% (4/6) |
ns | nsc | |
| PhE | 100% (6/6) |
100% (8/8) |
100% (6/6) |
86% (6/7) |
ns | nsc | |
| GABA | 29% (2/7) |
75% (6/8) |
67% (4/6) |
57% (4/7) |
ns | nsc | |
| NMDA | 100% (8/8) |
100% (8/8) |
100% (6/6) |
100% (7/7) |
ns | nsc | |
a
Mann-Kendall test for Trend, one-tailed.
b
ANOVA, two-tailed.
c
χ2 test, 2-tailed.