Table 4.
Molecular function GO enrichment of the 524 Caenorhabditis elegans genes whose orthologs were uniformly deleted in all parasitic species.
| Molecular functions (12426) | GO Descriptor | Under-represent P value | Over-represent P value |
|---|---|---|---|
| GO:0005524 | ATP binding | 1.00E + 00 | 9.61E − 26 |
| GO:0004889 | nicotinic acetylcholine-activated cation-selective channel activity | 1.00E + 00 | 1.55E − 25 |
| GO:0004674 | protein serine/threonine kinase activity | 1.00E + 00 | 9.24E − 19 |
| GO:0004713 | protein tyrosine kinase activity | 1.00E + 00 | 2.68E − 18 |
| GO:0016787 | hydrolase activity | 1.00E + 00 | 9.48E − 17 |
| GO:0004386 | helicase activity | 1.00E + 00 | 9.84E − 16 |
| GO:0005230 | extracellular ligand-gated ion channel activity | 1.00E + 00 | 3.68E − 12 |
| GO:0005328 | neurotransmitter:sodium symporter activity | 1.00E + 00 | 1.21E − 10 |
| GO:0015464 | acetylcholine receptor activity | 1.00E + 00 | 5.93E − 09 |
| GO:0019001 | guanyl nucleotide binding | 1.00E + 00 | 8.36E − 08 |
| GO:0004222 | metalloendopeptidase activity | 1.00E + 00 | 2.10E − 04 |
| GO:0004725 | protein tyrosine phosphatase activity | 1.00E + 00 | 4.18E − 04 |
| GO:0004879 | ligand-dependent nuclear receptor activity | 1.00E + 00 | 5.80E − 04 |
| GO:0019787 | small conjugating protein ligase activity | 1.00E + 00 | 7.09E − 04 |
| GO:0022848 | acetylcholine-gated cation channel activity | 1.00E + 00 | 9.93E − 04 |
| GO:0005388 | calcium-transporting ATPase activity | 1.00E + 00 | 1.31E − 03 |
| GO:0003677 | DNA binding | 9.99E − 01 | 1.60E − 03 |
| GO:0004016 | adenylate cyclase activity | 1.00E + 00 | 5.71E − 03 |
| GO:0004402 | histone acetyltransferase activity | 9.99E − 01 | 8.75E − 03 |
| GO:0004871 | signal transducer activity | 9.97E − 01 | 9.42E − 03 |
| GO:0016706 | oxidoreductase activity, acting on paired donors | 9.99E − 01 | 9.63E − 03 |
| GO:0017111 | nucleoside-triphosphatase activity | 9.96E − 01 | 9.69E − 03 |
| GO:0005509 | calcium ion binding | 9.92E − 01 | 1.52E − 02 |
| GO:0005330 | dopamine:sodium symporter activity | 1.00E + 00 | 3.15E − 02 |
| GO:0030297 | transmembrane receptor protein tyrosine kinase activator activity | 1.00E + 00 | 3.15E − 02 |
| GO:0035034 | histone acetyltransferase regulator activity | 1.00E + 00 | 3.15E − 02 |
| GO:0016849 | phosphorus-oxygen lyase activity | 9.91E − 01 | 3.95E − 02 |
| GO:0003712 | transcription cofactor activity | 9.92E − 01 | 4.74E − 02 |
| GO:0003723 | RNA binding | 1.76E − 02 | 9.96E − 01 |
| GO:0004888 | transmembrane receptor activity | 1.63E − 02 | 9.96E − 01 |
| GO:0003707 | steroid hormone receptor activity | 3.01E − 03 | 9.99E − 01 |
| GO:0003824 | catalytic activity | 8.97E − 04 | 1.00E + 00 |
| GO:0005215 | transporter activity | 3.18E − 04 | 1.00E + 00 |
| GO:0016491 | oxidoreductase activity | 1.26E − 04 | 1.00E + 00 |
| GO:0005488 | binding | 2.06E − 05 | 1.00E + 00 |
| GO:0003735 | structural constituent of ribosome | 3.38E − 05 | 1.00E + 00 |
| GO:0004497 | monooxygenase activity | 1.73E − 02 | 1.00E + 00 |
| GO:0008270 | zinc ion binding | 2.40E − 09 | 1.00E + 00 |
| GO:0009055 | electron carrier activity | 2.27E − 04 | 1.00E + 00 |
| GO:0016301 | kinase activity | 2.31E − 02 | 1.00E + 00 |
| GO:0016747 | transferase activity, transferring non amino-acyl groups | 2.03E − 02 | 1.00E + 00 |
| GO:0016758 | transferase activity, transferring hexosyl groups | 1.52E − 02 | 1.00E + 00 |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 2.31E − 02 | 1.00E + 00 |
| GO:0020037 | heme binding | 1.96E − 03 | 1.00E + 00 |
| GO:0046872 | metal ion binding | 2.90E − 02 | 1.00E + 00 |
| GO:0050660 | FAD binding | 3.09E − 02 | 1.00E + 00 |