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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Exp Dermatol. 2016 Dec;25(12):969–976. doi: 10.1111/exd.13108

Figure 3.

Figure 3

Macrophage depletion protects MRL/lpr mice from UVB-induced injury. Skin was obtained from UVB-exposed and non-exposed MRL/lpr Fn14 WT and KO mice. (a) Shown are representative images of IBA-1 stained sections from randomly selected 13–15 week old female UVB-irradiated MRL/lpr Fn14WT (n=11) and MRL/lpr Fn14KO mice (n=10). (b) Eight week old female MRL/lpr mice were treated with GW2580 via oral gavage for 16 days. During the last two days of GW2580 treatment, mice were exposed to UVB (50 mJ/cm2) and sacrificed 24 hours later. Shown are representative H&E images from GW (n=5) and PBS-treated (n=6) mice. The asterisk labels acanthotic epidermis, the arrowhead indicates parakeratosis, and the arrow points toward an epidermal pustule (left panel). (c) Representative H&E images of MRL/lpr Fn14WT (GW2580, n=3; PBS, n=2) and MRL/lpr Fn14KO mice (GW2580, n=3; PBS, n=2), treated and irradiated as above.