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. Author manuscript; available in PMC: 2016 Nov 29.
Published in final edited form as: Science. 2016 Jun 2;353(6299):aaf5573. doi: 10.1126/science.aaf5573

Figure 7. C2c2 as a putative RNA-targeting prokaryotic immune system.

Figure 7

The C2c2-crRNA complex recognizes target RNA via base pairing with the cognate protospacer and cleaves the target RNA. In addition, binding of the target RNA by C2c2-crRNA activates a non-specific RNase activity which may lead to promiscuous cleavage of RNAs without complementarity to the crRNA guide sequence. Through this non-specific RNase activity, C2c2 may also cause abortive infection via programmed cell death or dormancy induction.