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Flow chart summarizing the screening process and DR experiments. A library of 17,500 compounds was screened using stx2::GFP, rpsm::GFP and sulA::GFP reporter fusions. Seventy-six compounds that showed significant activity on stx2::GFP and suIA::GFP were identified from this initial screen, and further dose-response assays narrowed this to six hits that reduced stx2::GFP expression in a dose-dependent manner. The single most potent compound was taken forward for mechanistic studies.
