FIGURE 1.

Anti-proliferative effects of sorafenib and OSU-2S in HCC cell lines. (A) Chemical structures of OSU-2S and sorafenib. HCC cells were treated with sorafenib (B) or OSU-2S (C) at the indicated concentrations in 10% FBS-supplemented Dulbecco’s modified Eagle’s medium (DMEM) in 96-well plates for 48 h, and cell viability was assessed by MTT assays. Points, mean; bars, SD (n = 6). (D) The IC₅₀ values of sorafenib and OSU-2S in four HCC cell lines calculated from MTT assays. All data are depicted as mean ± SD (n = 6).