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. 2016 Nov 30;7:463. doi: 10.3389/fphar.2016.00463

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Copyright © 2016 Omar, Tolba, Hung and Al-Tel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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OSU-2S/sorafenib synergistic combination. (A) HepG2, Huh7, Hep3B, and PLC5 cell lines were treated with sorafenib or OSU-2S at the indicated concentrations in 10% FBS-DMEM plates for 48 h, and cell viability was assessed by MTT assays. Columns, mean; bars, SD (n = 6). (B) OSU-2S/sorafenib combination algebraic estimate calculated by Calcusyn software. (C) A table showing the fraction affected (Fa) and OSU-2S/sorafenib combination indices (CI) at the indicated dose levels in four different HCC cell lines.