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Knockdown of p53 in HepG2 cells increases the resistance to both sorafenib and OSU-2S. (A) Western blot analysis of the differential expression levels of p53 in untransfected HepG2 cells versus HepG2 cells transfected by scrambled shRNA or shRNA against p53. Effect of p53 knockdown on the sensitivity of HepG2 cells to (B) sorafenib or (C) OSU-2S-mediated inhibition of cell viability measured by MTT assay. Points, mean; bars, SD (n = 6).
