Table 4.
Univariate analysis of factors influencing leucopenia using time dependent Cox proportional hazards regression models. The total number of events among the whole protocol visits were studied.
| * Covariate | Category | HR (95%CI) | p value |
|---|---|---|---|
| EC_MPS dose | Per unit increase | 0.999 (0.998,1.000) | 0.2220 |
|
| |||
| Age | Per year increase | 1.03 (0.99,1.07) | 0.1400 |
|
| |||
| Sex | F vs M | 1.66 (0.73,3.76) | 0.2270 |
|
| |||
| Randomization group | with vs. without steroids | 0.61 (0.27,1.38) | 0.2380 |
|
| |||
| IMPDH2 IVS7+10 T>C (rs11706052) | TT vs. TC/CC | 6.14 (0.83,45.58) | 0.0761 |
|
| |||
| IMPDH1 C>T (rs2278923) | CT vs. CC | 4.84 (1.12,20.97) | 0.0351 |
| TT vs. CC | 3.35 (0.65,17.33) | 0.1489 | |
|
| |||
| IMPDH1 C>T (rs2278924) | CT vs. CC | 1.42 (0.60,3.34) | 0.4200 |
| TT vs. CC | 0.98 (0.21,4.56) | 0.9770 | |
|
| |||
| ABCC2 -24 C>T (rs717620) | CT vs. CC | 0.83 (0.35,2.02) | 0.6890 |
|
| |||
| ABCC2 1249 G>A (rs2273697) | GG vs. GA/AA | 0.89 (0.39,2.03) | 0.7880 |
|
| |||
| ABCC2 3972 C>T (rs3740066) | CT vs. CC | 0.42 (0.14,1.23) | 0.1147 |
| TT vs. CC | 2.45 (0.99,6.07) | 0.0533 | |
|
| |||
| ABCC2 4544 G>A (rs8187710) | GG vs. GA/AA | 4.82 (0.65,35.81) | 0.1240 |
|
| |||
| SLCO1B3 334 T>G (rs4149117) | TG/TT vs. GG | 1.60 (0.70,3.65) | 0.2620 |
|
| |||
| UGT1A8 518 C>G (rs1042597) | CG/GG vs. CC | 1.64 (0.73,3.67) | 0.2270 |
|
| |||
| UGT1A9 -2152 C>T (rs17868320) | CT vs. CC | 0 (0,Inf) | 1.0000 |
|
| |||
| UGT1A9 -275 T>A | TT vs. TA/AA | 2.38 (0.32,17.67) | 0.3970 |
|
| |||
| UGT 2B7 -840 G>A (rs7438135) | GA vs. AA | 0.57 (0.22,1.46) | 0.2430 |
| GG vs. AA | 0.69 (0.24,1.99) | 0.4910 | |
|
| |||
|
CYP2C8 G>A rs11572076 |
GG vs. GA | 0.14 (0.03,0.59) | 0.0078 |
|
| |||
|
HUS1 G>A rs1056663 |
GA vs. AA | 0.70 (0.23,2.08) | 0.5180 |
| GG vs. AA | 1.07 (0.36,3.21) | 0.9000 | |
|
| |||
|
IL12A G>A rs568408 |
GG vs. GA/AA | 0.55 (0.22,1.41) | 0.2140 |
*
cyclosporine C2 was not evaluated due to a high number of missing values (487/1398), totally at random