Table 5.
Univariate analysis of factors influencing anemia using time dependent Cox proportional hazards regression models. The total number of events among the whole protocol visits were studied.
| Covariate | Category | HR (95%CI) | p value |
|---|---|---|---|
| EC_MPS dose | Per unit increase | 1.004 (1.003,1.005) | <0.0001 |
|
| |||
| Age | Per year increase | 1.003(0.989, 1.016) | 0.690 |
|
| |||
| Sex | F vs M | 0.95 (0.69,1.31) | 0.768 |
|
| |||
| Randomization group | with vs. without steroids | 0.83 (0.61,1.11) | 0.207 |
|
| |||
| IMPDH2 IVS7+10 T>C (rs11706052) | TT vs. TC/CC | 1.11 (0.77,1.62) | 0.572 |
|
| |||
| IMPDH1 C>T (rs2278923) | CT vs. CC | 0.95 (0.67,1.34) | 0.769 |
| TT vs. CC | 1.09 (0.72,1.63) | 0.682 | |
|
| |||
| IMPDH1 C>T (rs2278924) | CT vs. CC | 0.99 (0.72,1.36) | 0.958 |
| TT vs. CC | 1.12 (0.70,1.80) | 0.630 | |
|
| |||
| ABCC2 -24 C>T (rs717620) | CT vs. CC | 1.42 (1.06,1.92) | 0.0202 |
|
| |||
| ABCC2 1249 G>A (rs2273697) | GG vs. GA/AA | 1.14 (0.83,1.56) | 0.4170 |
|
| |||
| ABCC2 3972 C>T (rs3740066) | CT vs. CC | 1.35 (0.97,1.89) | 0.0772 |
| TT vs. CC | 1.43 (0.91,2.25) | 0.1235 | |
|
| |||
| ABCC2 4544 G>A (rs8187710) | GG vs. GA/AA | 0.77 (0.53,1.12) | 0.1790 |
|
| |||
| SLCO1B3 334 T>G (rs4149117) | TG/TT vs. GG | 1.14 (0.82,1.58) | 0.447 |
|
| |||
| UGT1A8 518 C>G (rs1042597) | CG/GG vs. CC | 1.02 (0.75,1.37) | 0.914 |
|
| |||
| UGT1A9 -2152 C>T (rs17868320) | CT vs. CC | 1.54 (0.85,2.76) | 0.150 |
|
| |||
| UGT1A9 -275 T>A | TT vs. TA/AA | 0.65 (0.43,0.99) | 0.0473 |
|
| |||
| UGT 2B7 -840 G>A (rs7438135) | GA vs. AA | 1.51 (1.03,2.22) | 0.036 |
| GG vs. AA | 1.63 (1.07,2.50) | 0.023 | |
|
| |||
|
CYP2C8 G>A rs11572076 |
GG vs. GA | 1.88 (0.26,13.43) | 0.529 |
|
| |||
|
HUS1 G>A rs1056663 |
GA vs. AA | 0.76 (0.52,1.12) | 0.162 |
| GG vs. AA | 0.89 (0.59,1.33) | 0.567 | |
|
| |||
|
IL12A G>A rs568408 |
GG vs. GA/AA | 0.98 (0.66,1.43) | 0.905 |
*
cyclosporine C2 was not evaluated due to a high number of missing values (514/1279), totally at random