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. 2016 Nov 30;10:271. doi: 10.3389/fncel.2016.00271

Figure 7.

Figure 7

Sevoflurane enhanced neuron resistance to global cerebral injury by the PI3K/AKT signaling pathway. (A,C) Western blots analysis for p-Akt, mitochondrial biogenesis related proteins, and mitochondria-specific antioxidant enzymes at 24 h after reperfusion. (B,D) Quantitative analysis for the level of p-Akt, mitochondrial biogenesis-related proteins and mitochondria-specific antioxidant enzymes. (E–G) Effect of wortmannin on sevoflurane post-conditioning-inhibited mROS generation, loss of MMP and opening of MPTP. Data are expressed as mean ± S.D. n = 6–8 rats for each group. P < 0.05 vs. SE+W group; #P < 0.05 vs. the CA group.