Table 6.
Summary of clinical pathways of 10,000 simulated patients
| Patient pathways | Simulation period (years) | ||||||||||||
| ADA sequence | 0–0.5 | 0.5–1.0 | 1.0–1.5 | 1.5–2.0 | 2.0–2.5 | 2.5–3.0 | 3.0–3.5 | 3.5–4.0 | 4.0–4.5 | 4.5–5.0 | 5.0–5.5 | 99.5–100.0 | |
| AdaP1 | Cost | 1,175.33 € | 2,336.49 € | 3,480.62 € | 4,607.97 € | 5,718.77 € | 6,813.28 € | 7,891.73 € | 8,954.36 € | 10,001.40 € | 11,033.07 € | 12,049.62 € | 56,601.17 € |
| HAQ | 0.95 | 0.48 | 0.48 | 0.48 | 0.48 | 0.48 | 0.48 | 0.48 | 0.48 | 0.48 | 0.48 | Dead | |
| QALYs | 0.06 | 0.14 | 0.22 | 0.33 | 0.45 | 0.58 | 0.73 | 0.90 | 1.09 | 1.29 | 1.52 | 35.27 | |
| AdaP2 | Cost | 8,475.97 € | 16,830.66 € | 25,062.79 € | 33,174.15 € | 41,166.50 € | 49,041.60 € | 56,801.17 € | 64,446.90 € | 71,980.46 € | 79,403.50 € | 86,717.64 € | 259,074.20 € |
| HAQ | 1.76 | 1.33 | 1.33 | 1.33 | 1.33 | 1.33 | 1.33 | 1.33 | 1.33 | 1.33 | 1.33 | Dead | |
| QALYs | 0.09 | 0.20 | 0.33 | 0.47 | 0.64 | 0.83 | 1.05 | 1.28 | 1.54 | 1.83 | 2.14 | 19.74 | |
| AdaP3 | Cost | 5,049.70 € | 5,201.14 € | 5,350.35 € | 5,497.38 € | 5,642.25 € | 5,784.99 € | 5,925.64 € | 6,064.23 € | 6,200.78 € | 6,335.33 € | 6,467.90 € | 22,217.08 € |
| HAQ | 1.51 | 1.09 | 1.09 | 1.09 | 1.09 | 1.09 | 1.09 | 1.09 | 1.09 | 1.09 | 1.09 | Dead | |
| QALYs | 0.08 | 0.17 | 0.28 | 0.41 | 0.56 | 0.73 | 0.92 | 1.13 | 1.36 | 1.62 | 1.90 | 13.40 | |
| AdaP4 | Cost | 12,567.52 € | 16,014.09 € | 19,413.13 € | 22,762.30 € | 26,062.34 € | 29,313.96 € | 32,517.88 € | 35,674.80 € | 38,785.40 € | 49,655.85 € | 62,241.19 € | 283,043.36 € |
| HAQ | 1.83 | 1.69 | 1.04 | 1.04 | 1.04 | 1.04 | 1.04 | 1.04 | 1.04 | 1.04 | 1.69 | Dead | |
| QALYs | 0.04 | 0.20 | 0.38 | 0.58 | 0.81 | 1.05 | 1.32 | 1.61 | 1.93 | 2.17 | 2.54 | 7.33 | |
| AdaP10000 | Cost | 5,049.70 € | 10,028.39 € | 14,934.04 € | 19,767.72 € | 24,530.49 € | 29,223.39 € | 33,847.43 € | 41,957.29 € | 44,593.79 € | 47,194.35 € | 49,756.75 € | 99,881.03 € |
| HAQ | 1.29 | 0.66 | 0.66 | 0.66 | 0.66 | 0.66 | 0.66 | 0.66 | 1.29 | 0.35 | 0.35 | Dead | |
| QALYs | 0.09 | 0.20 | 0.32 | 0.46 | 0.62 | 0.80 | 1.00 | 1.13 | 1.40 | 1.68 | 1.99 | 22.02 | |
| Mean cost (10,000 patients) = 210,481 € | |||||||||||||
| Mean QALYs (10,000 patients) = 9.92 | |||||||||||||
| Patient pathways | Simulation period (years) | ||||||||||||
| csDMARD sequence | 0–0.5 | 0.5–1.0 | 1.0–1.5 | 1.5–2.0 | 2.0–2.5 | 2.5–3.0 | 3.0–3.5 | 3.5–4.0 | 4.0–4.5 | 4.5–5.0 | 5.0–5.5 | 99.5–100.0 | |
| ConvP1 | Cost | 3,211.12 € | 4,651.77 € | 7,623.18 € | 10,698.02 € | 13,727.75 € | 16,713.04 € | 19,654.52 € | 27,300.25 € | 34,833.82 € | 42,256.85 € | 49,570.99 € | 256,125.65 € |
| HAQ | 0.95 | 0.81 | 0.36 | 0.81 | 0.88 | 0.94 | 1.01 | 1.07 | 1.14 | 1.20 | 1.27 | Dead | |
| QALYs | 0.03 | 0.11 | 0.17 | 0.23 | 0.30 | 0.38 | 0.46 | 0.56 | 0.66 | 0.78 | 0.90 | 4.57 | |
| ConvP2 | Cost | 8,475.97 € | 11,922.54 € | 15,321.58 € | 18,670.75 € | 21,970.79 € | 25,222.41 € | 28,426.33 € | 31,583.24 € | 34,693.85 € | 37,758.81 € | 40,778.81 € | 222,335.27 € |
| HAQ | 1.76 | 1.62 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | Dead | |
| QALYs | 0.04 | 0.20 | 0.37 | 0.56 | 0.78 | 1.01 | 1.27 | 1.55 | 1.86 | 2.19 | 2.54 | 9.61 | |
| ConvP3 | Cost | 5,049.70 € | 5,201.14 € | 5,350.35 € | 5,497.38 € | 5,642.25 € | 5,642.25 € | 6,042.47 € | 6,181.06 € | 6,317.61 € | 6,452.16 € | 6,584.74 € | 7,459.88 € |
| HAQ | 1.51 | 1.02 | 1.02 | 1.02 | 1.02 | 1.02 | 1.51 | 1.36 | 1.43 | 1.49 | 1.56 | Dead | |
| QALYs | 0.09 | 0.19 | 0.31 | 0.45 | 0.61 | 0.72 | 0.87 | 1.03 | 1.21 | 1.39 | 1.59 | 3.21 | |
| ConvP4 | Cost | 12,567.52 € | 21,201.70 € | 33,256.99 € | 45,282.45 € | 57,131.49 € | 68,806.69 € | 80,310.61 € | 91,645.76 € | 102,814.61 € | 117,286.83 € | 131,546.73 € | 364,983.07 € |
| HAQ | 1.83 | 1.68 | 1.24 | 1.68 | 1.75 | 1.81 | 1.88 | 1.94 | 2.01 | 2.07 | 2.14 | Dead | |
| QALYs | 0.04 | 0.18 | 0.26 | 0.35 | 0.46 | 0.57 | 0.69 | 0.83 | 0.97 | 1.13 | 1.30 | 2.40 | |
| ConvP10000 | Cost | 9,144.37 € | 14,402.55 € | 19,308.20 € | 28,058.97 € | 36,681.36 € | 45,177.25 € | 53,548.50 € | 61,796.94 € | 69,924.37 € | 77,932.57 € | 85,823.28 € | 118,358.40 € |
| HAQ | 1.29 | 1.17 | 1.03 | 1.10 | 1.16 | 1.23 | 1.29 | 1.36 | 1.42 | 1.49 | 1.55 | Dead | |
| QALYs | 0.03 | 0.10 | 0.17 | 0.25 | 0.34 | 0.44 | 0.55 | 0.67 | 0.80 | 0.94 | 1.09 | 3.96 | |
| Mean cost (10,000 patients) = 169,016 € | |||||||||||||
| Mean QALYs (10,000 patients) = 7.07 | |||||||||||||