Table 7.
Deterministic sensitivity analysis
| ADA | ADA | csDMARDs | csDMARDs | ICUR ADA | ICUR ADA | ICUR change compared to base case | % Change compared to base case | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Retail price | Undistorted price | Retail price | Undistorted price | Retail price | Undistorted price | Retail price | Undistorted price | Retail price | Undistorted price | |||
| BASE CASE | Costs | Direct | 76,118 € | 54,507 € | 6,318 € | 5,269 € | 24,492 € | 17,277 € | ||||
| Total | 210,481 € | 188,870 € | 169,016 € | 167,967 € | 14,550 € | 7,335 € | ||||||
| QALYs | 9.92 | 9.92 | 7.07 | 7.07 | ||||||||
| Baseline age 30 | Costs | Direct | 95,238 € | 68,368 € | 9,046 € | 7,590 € | 19,804 € | 13,965 € | −4,688 € | −3,312 € | −19 % | −19 % |
| Total | 444,974 € | 418,105 € | 429,773 € | 428,317 € | 3,493 € | −2,346 € | −11,057 € | −9,681 € | −76 % | −132 % | ||
| QALYs | 14.90 | 14.90 | 10.55 | 10.55 | ||||||||
| Baseline age 40 | Costs | Direct | 92,343 € | 66,182 € | 8,092 € | 6,775 € | 22,778 € | 16,061 € | −1,713 € | −1,215 € | −7 % | −7 % |
| Total | 356,685 € | 330,524 € | 329,333 € | 328,016 € | 7,395 € | 678 € | −7,155 € | −6,657 € | −49 % | −91 % | ||
| QALYs | 13.06 | 13.06 | 9.36 | 9.36 | ||||||||
| Baseline age 60 | Costs | Direct | 67,358 € | 48,211 € | 5,468 € | 4,550 € | 26,137 € | 18,439 € | 1,645 € | 1,162 € | 7 % | 7 % |
| Total | 151,573 € | 132,427 € | 108,217 € | 107,300 € | 18,310 € | 10,612 € | 3,760 € | 3,277 € | 26 % | 45 % | ||
| QALYs | 8.36 | 8.36 | 5.99 | 5.99 | ||||||||
| Baseline HAQ 1.0 | Costs | Direct | 75,076 € | 53,771 € | 6,269 € | 5,229 € | 26,010 € | 18,350 € | 1,518 € | 1,073 € | 6 % | 6 % |
| Total | 165,843 € | 144,538 € | 123,945 € | 122,905 € | 15,838 € | 8,178 € | 1,288 € | 843 € | 9 % | 11 % | ||
| QALYs | 10.72 | 10.72 | 8.07 | 8.07 | ||||||||
| Baseline HAQ 2.0 | Costs | Direct | 76,607 € | 54,853 € | 6,285 € | 5,245 € | 26,281 € | 18,540 € | 1,789 € | 1,263 € | 7 % | 7 % |
| Total | 245,383 € | 223,629 € | 198,697 € | 197,656 € | 17,448 € | 9,707 € | 2,898 € | 2,372 € | 20 % | 32 % | ||
| QALYs | 8.67 | 8.67 | 5.99 | 5.99 | ||||||||
| Baseline HAQ 2.5 | Costs | Direct | 76,869 € | 55,033 € | 6,278 € | 5,237 € | 31,950 € | 22,538 € | 7,459 € | 5,261 € | 30 % | 30 % |
| Total | 282,295 € | 260,458 € | 226,992 € | 225,951 € | 25,031 € | 15,618 € | 10,481 € | 8,284 € | 72 % | 113 % | ||
| QALYs | 6.78 | 6.78 | 4.57 | 4.57 | ||||||||
| 5-year results | Costs | Direct | 27,429 € | 19,628 € | 1,934 € | 1,582 € | 86,438 € | 61,185 € | 61,947 € | 43,908 € | 253 % | 254 % |
| Total | 71,005 € | 63,205 € | 53,749 € | 53,397 € | 58,503 € | 33,250 € | 43,954 € | 25,915 € | 302 % | 353 % | ||
| QALYs | 1.65 | 1.65 | 1.35 | 1.35 | ||||||||
| 10-year results | Costs | Direct | 50,187 € | 35,836 € | 3,377 € | 2,782 € | 52,128 € | 36,810 € | 27,636 € | 19,534 € | 113 % | 113 % |
| Total | 130,019 € | 115,669 € | 101,776 € | 101,180 € | 31,452 € | 16,135 € | 16,902 € | 8,800 € | 116 % | 120 % | ||
| QALYs | 4.19 | 4.19 | 3.29 | 3.29 | ||||||||
| 0 % cost discounting | Costs | Direct | 107,825 € | 77,278 € | 9,385 € | 7,867 € | 33,740 € | 23,790 € | 9,248 € | 6,513 € | 38 % | 38 % |
| Total | 290,850 € | 260,302 € | 231,072 € | 229,554 € | 20,488 € | 10,539 € | 5,939 € | 3,204 € | 41 % | 44 % | ||
| QALYs | 9.98 | 9.98 | 7.06 | 7.06 | ||||||||
| 6 % cost discounting | Costs | Direct | 59,773 € | 42,763 € | 4,683 € | 3,888 € | 20,844 € | 14,709 € | −3,648 € | −2,568 € | −15 % | −15 % |
| Total | 163,092 € | 146,082 € | 130,289 € | 129,494 € | 12,411 € | 6,276 € | −2,138 € | −1,058 € | −15 % | −14 % | ||
| QALYs | 9.89 | 9.89 | 7.24 | 7.24 | ||||||||
| 3 % QALY discounting | Costs | Direct | 76,659 € | 54,887 € | 6,287 € | 5,247 € | 37,726 € | 26,612 € | 13,235 € | 9,335 € | 54 % | 54 % |
| Total | 208,460 € | 186,688 € | 166,432 € | 165,392 € | 22,531 € | 11,417 € | 7,982 € | 4,082 € | 55 % | 56 % | ||
| QALYs | 6.84 | 6.84 | 4.98 | 4.98 | ||||||||
| HUI-3 for quality of life |
Costs | Direct | 76,228 € | 54,583 € | 6,319 € | 5,271 € | 29,678 € | 20,934 € | 5,186 € | 3,657 € | 21 % | 21 % |
| Total | 209,029 € | 187,384 € | 168,860 € | 167,812 € | 17,053 € | 8,309 € | 2,503 € | 974 € | 17 % | 13 % | ||
| QALYs | 7.41 | 7.41 | 5.05 | 5.05 | ||||||||
| Direct costs +10 % |
Costs | Direct | 83,730 € | 59,957 € | 6,950 € | 5,796 € | 26,941 € | 19,004 € | 2,449 € | 1,728 € | 10 % | 10 % |
| Total | 218,093 € | 194,321 € | 169,647 € | 168,494 € | 16,999 € | 9,062 € | 2,449 € | 1,728 € | 17 % | 24 % | ||
| QALYs | 9.92 | 9.92 | 7.07 | 7.07 | ||||||||
| Direct costs −10 % |
Costs | Direct | 68,506 € | 49,056 € | 5,686 € | 4,742 € | 22,043 € | 15,549 € | −2,449 € | −1,728 € | −10 % | −10 % |
| Total | 202,869 € | 183,419 € | 168,384 € | 167,440 € | 12,100 € | 5,607 € | −2,449 € | −1,728 € | −17 % | −24 % | ||
| QALYs | 9.92 | 9.92 | 7.07 | 7.07 | ||||||||
| Indirect costs +10 % |
Costs | Direct | 76,118 € | 54,507 € | 6,318 € | 5,269 € | 24,492 € | 17,277 € | 0 € | 0 € | 0 % | 0 % |
| Total | 223,917 € | 202,306 € | 185,285 € | 184,236 € | 13,555 € | 6,340 € | −994 € | −994 € | −7 % | −14 % | ||
| QALYs | 9.92 | 9.92 | 7.07 | 7.07 | ||||||||
| Indirect costs −10 % |
Costs | Direct | 76,118 € | 54,507 € | 6,318 € | 5,269 € | 24,492 € | 17,277 € | 0 € | 0 € | 0 % | 0 % |
| Total | 197,045 € | 175,434 € | 152,746 € | 151,697 € | 15,544 € | 8,329 € | 994 € | 994 € | 7 % | 14 % | ||
| QALYs | 9.92 | 9.92 | 7.07 | 7.07 | ||||||||