Table 1.

Outcome measures.

Cohort	Primary outcome measures
Breast cancer	Invasive disease-free survival (IDFS) [28]
Colorectal cancer	Disease-free survival (DFS)
Gastro-oesophageal cancer	Overall survival
Prostate cancer	Biochemical recurrence-free survival (bRFS)
All cohorts combined	Overall survival
Cohort	Secondary outcome measures
All cohorts	Overall survival (except for gastro-oesophageal cohort)
	Adherence
	Toxicity
	Serious haemorrhage CTCAE (v4) grade 3 or greater
	Serious vascular events
	Thrombotic events
	Diabetes and associated complications
	Second malignancies
	Age-related macular degeneration
	Cognitive assessment (using the MOCA-blind questionnaire)
	Dementia
	Comorbidities (using the Charlson Index)
	Obesity (using the Body Mass Index)
	Functional capacity (using the VES-13 questionnaire)
Breast	Breast cancer-specific survival
	Bone metastases-free survival
	Invasive disease-free survival-ductal carcinoma insitu (IDFS-DCIS)
Colorectal	Colorectal cancer-specific survival
Gastro-oesophageal	Disease-free survival
Prostate	Prostate cancer-specific survival
	Time to initiation of salvage treatment
	Bone metastases-free survival