Assessments		Prior to registration	Prior to randomisation (end of run-in period)	Months since randomisation
				3	6	9	12	18	24	30	36	42	48	54	60
All cohorts
Main assessments	Registration assessmentsa	✓
	End of run-in assessmentb		✓
	Follow-up assessmentsc			✓	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓
Intermittent assessments	VES-13 questionnaire (65 ≥ years at registration)	✓													✓
	Cognitive assessment	✓					✓								✓
Blood tests	FBC, LFT, U&E & eGFR	✓	✓		✓		✓		✓		✓		✓		✓
	C-Reactive Protein (CRP)	✓			✓		✓
	Fasting lipid profile	✓
Other tests	Tumour and blood sample	✓
Breast cohort
Imaging	Mammography	✓					✓		✓		✓		✓		✓
Colorectal cohort
Imaging and procedures	CT (chest/abdomen/pelvis)	✓					✓		✓						✓
	Colonoscopy	✓						✓		✓					✓
Blood tests	CEA test	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓
Prostate cohort
Blood tests	PSA	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓
Gastro-oesophageal cohort
No cohort specific investigations

^aRegistration assessments include: eligibility, co-enrolment (if applicable), blood pressure, height, weight, blood results, concomitant medication and comorbidities.

^bEnd of run-in assessments include: symptoms and toxicity, adherence, blood pressure.

^cFollow-up assessments include: symptoms and toxicity, adherence, blood pressure, weight, concomitant medication.