Table 1.

Tregs primed by IDO⁺pDCs delay and dampen clinical EAE. CD4⁺CD25^hi cells were purified from dLNs of WT → WT (WT Tregs), pIII + IV^−/− → WT (pIII + IV^−/− Tregs) and IDO^−/− → WT (IDO^−/− Tregs) BM chimeras 10 days after EAE induction, and transferred into WT recipients further immunized for EAE the day after. Mean and cumulative clinical scores, mean day of onset and disease incidence are indicated (two-way ANOVA with Bonferroni post Hoc test). Results are representative of 2 independent experiments. ***P < 0.001.

	Mean clinical score	Cumulative clinical score	Mean day of onset	Incidence
Ctrl EAE	1.32 ± 0.32	25.13	10	100%
EAE + WT Tregs	***0.57 ± 0.17	10.80	16	80%
EAE + IDO−/− Tregs	1.70 ± 0.39	32.25	11	100%
EAE + pIII + IV−/− Tregs	1.36 ± 0.36	25.88	12	100%