Table 3.
Antiretroviral concentrations in CSF and plasma
| n | Drug concentration (ng/ml) | ||
|---|---|---|---|
| Geo mean | 95 % CI | ||
| Plasma | |||
| Tenofovir | 62 | 89.5 | 73.1–110.7 |
| Emtricitabine | 65 | 187.9 | 136.5–264.9 |
| Lamivudine | 24 | 383.7 | 225.4–688.7 |
| Darunavir | 55 | 2971.7 | 2393.3–3715.4 |
| Atazanavir | 19 | 729.5 | 418.8–1339.7 |
| Lopinavir | 3 | 8570.4 | 7798.3–9440.6 |
| Ritonavir | 15 | 116.1 | 55.7–277.3 |
| Efavirenz | 27 | 1741.8 | 1349.0–2269.9 |
| Nevirapine | 10 | 4226.7 | 2691.5–6807.7 |
| Etravirine | 4 | 269.2 | 64.4–1836.5 |
| Rilpivarine | 4 | 68.1 | 36.0–144.2 |
| Maraviroc | 8 | 172.2 | 88.9–367.3 |
| Raltegravir | 11 | 413.9 | 174.1–1135.0 |
| CSF | |||
| Darunavir | 54 | 35.2 | 27.8–45.4 |
| Atazanavir | 20 | 6.4 | 4.1–11.5 |
| Lopinavir | 3 | 9.6 | 4.1–37.3 |
| Efavirenz | 26 | 14.7 | 11.4–19.4 |
| Nevirapine | 12 | 1559.6 | 1127.2–2197.9 |
| Maraviroc | 9 | 6.5 | 2.75–31.6 |
| Raltegravir | 14 | 25.9 | 18.1–38.7 |
Geometric mean and 95 % confidence interval for drug concentrations in plasma and CSF. No significant associations were observed with CSF/plasma discordance