Table 1.
Demographic, HIV, and cognitive characteristics of the study population
| Characteristicsa | All n = 40 | Youth (18–24 yearsold) n = 20 | Older adults (40–46 years old) n = 20 | p valueb |
|---|---|---|---|---|
| Demographic variables | ||||
| Male sex | 35 (88) | 18 (90) | 17 (85) | 0.633 |
| Black race | 13 (33) | 6 (30) | 7 (35) | 0.986 |
| Age (years) | 32 (22–42) | 22 (20.5–23.5) | 42 (40–43.5) | <0.001 |
| HIV variables | ||||
| Duration of HIV (years) | 3.1 (0.5–11.2) | 1.2 (0.3–3.1) | 8.3 (3.3–14.1) | 0.005 |
| Currently using ART | 23 (58) | 9 (45) | 14 (70) | 0.053 |
| CD4 nadir | 233 (59–410) | 298 (199–521) | 109 (35–356) | 0.020 |
| Plasma CD4+ count: 50–199 | 6 (15) | 2 (10) | 4 (20) | 0.587 |
| 200–349 | 10 (25) | 6 (30) | 4 (20) | – |
| ≥ 350 | 24 (60) | 12 (60) | 12 (60) | – |
| Plasma HIV-1 RNA (log) | 2.96 (1.70–3.90) | 2.96 (1.60–4.23) | 2.96 (1.70–3.55) | 0.815 |
| CSF HIV-1 RNA (log) | 1.70 (1.70–2.36) | 1.70 (1.60–2.71) | 1.70 (1.70–2.24) | 0.750 |
| Cognitive variables | ||||
| Education (years) | 12 (11–13) | 12 (11.5–13) | 13 (10.5–14.5) | 0.335 |
| WRAT score | 93.5 (83–108) | 102 (90–112) | 90 (76–100) | 0.025 |
| HAND normal | 17 (43) | 7 (35) | 10 (50) | 0.548 |
| ANI, n(%) | 17 (43) | 10 (50) | 7 (35) | – |
| MND, n(%) | 1 (3) | 0 (0) | 1 (5) | – |
| HAD, n(%) | 1 (3) | 1 (5) | 0 | – |
| Not classified | 4 (10) | 2 (10) | 2 (10) | – |
aCategorical variables are described using n(%). Continuous variables are described using median (IQR)
b p values to compare characteristics between age groups were calculated using chi-square tests for categorical variables and the Wilcoxan rank-sum (Mann-Whitney U) tests for continuous variables