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. 2016 Nov 30;6:38037. doi: 10.1038/srep38037

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(A) Overview of HER2 status, molecular subtype and specific ERBB2 mutation for those individuals with detected ERBB2 (HER2) somatic mutations. All tumors with somatic mutations in ERBB2 (HER2) were found to be HER2-negative according to both routine pathology and RNAseq-based classification, indicating normal HER2 expression levels. (B) Overview of transcriptomic grade, ER status, HER2 status, molecular subtype and BRCA1/2 mutations status of those individuals with detected germline or somatic mutations in either BRCA1 or BRCA2. Tumors in patients with germline alterations in BRCA1 are predominantly of the Basal-like subtype. (Key: TG = transcriptomic grade. Status: 0 = negative/low; 1 = positive/high).