| Dicer-2 |
RNaseIII, processing of long dsRNA into siRNAs |
24–27 |
| R2D2 |
dsRNA-binding, co-factor of Dicer-2 |
|
| Ago-2 |
Argonaute, catalytic subunit of RISC |
|
| RNAi core machinery: miRNA pathway |
| Drosha |
RNase III, cleavage of pri-miRNA to pre-miRNA |
24–27 |
| DGCR8 |
dsRNA-binding, co-factor of Drosha |
|
| Dicer-1 |
RNase III, conversion of pre-miRNA to miRNA |
|
| Loquacious |
dsRNA-binding, co-factor of Dicer-1 |
|
| Ago-1 |
Argonaute, catalytic subunit of RISC |
|
| RNAi core machinery: piRNA pathway |
| Piwi/Aubergine |
Argonaute (PIWI subfamily), catalytic subunit of RISC |
28 |
| Ago-3 |
Argonaute (PIWI subfamily), catalytic subunit of RISC |
|
| Auxiliary factors (RISC) |
| FXMR |
Fragile-X-related protein, component of RISC complex in S2 cells, RNA binding RGG and KH motifs |
66 |
| RNA helicase DDX |
DEAD-box RNA helicase, required for RNAi |
67 |
| Staufen |
Tubulin-binding & dsRNA-binding domain transport of |
68 |
| Neuron-specific Staufen |
mRNA |
|
| Maelstrom |
piRNA pathway domain weak similarity to HMG box, Mael domain with weak homology with the DnaQ-H 3′-to-5′ exonuclease |
69 |
| PRMT5 |
Protein methyltransferase; methylates Piwi proteins at conserved Arg-residues |
70 |
| Clp-1 |
RNA kinase, phosphorylation of siRNAs |
71 |
| DsRNA uptake |
| Sid-1 |
Homolog of putative dsRNA transporter in C. elegans
|
72 |
| Antiviral RNAi |
| Ars2 |
Regulator of siRNA- and miRNA-mediated silencing, suppressor of RNA virus infection |
73 |
| Egghead |
Seven transmembrane- domain glycosyltransferase, uptake of dsRNA, innate immunity against RNA virus (Drosophila) |
52 |
| Nuclease |
| Nibbler (mut-7) |
Processing of 3′ends of miRNAs (Drosophila) |
74 |
