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. 2016 Nov 30;6:38138. doi: 10.1038/srep38138

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The cells were treated with PA and/or GCM at the concentrations indicted for 24 h and then the cell were collected for analysis of mitochondrial pathway. (A) Protective effect of GCM on PA-disrupted mitochondrial membrane potential in HepG2 cells determined by JC-1 staining. (B) Changes of Bcl-2 family proteins by PA in the presence or absence of GCM analyzed by western blotting in HepG2 cells. (C) Influences of GCM on Bcl-2 family protein in liver tissues of mice fed with MCD diet detected by western blotting.