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. 2016 Nov 30;6:38138. doi: 10.1038/srep38138

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Copyright © 2016, The Author(s)

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(A and B) GCM activated autophagy in vitro analyzed by immunofluorescence staining for LC3 distribution or western blotting analysis for conversion of the LC3-I to LC3-II. C. GCM activated autophagy in vivo assessed by western blotting. (D) GCM increased autophagic flux in the presence of PA. The cells were treated with PA/GCM for 24 h in the presence or absence of 100 nM bafilomycin A1 (added 2 h before cells harvest) and then LC3 was analyzed by western blotting. (E). GCM promoted p62 degradation in the presence of PA. The cells were treated with PA and/or GCM in the presence or absence of CHX for 16 h and then p62 was analyzed by western blotting.